Fig. 6.
a AHR to Mch was assessed 24 h after final chronic OVA and/or chronic ETS challenge in intubated and ventilated mice. Results are expressed as Raw in mice exposed to nebulized Mch (3, 24 and 48 mg/ml). In ETS-exposed mice challenged with OVA, ISS significantly reduced AHR (p < 0.04; Mch 48 mg/ml; ETS + OVA + ISS vs. ETS + OVA). ISS also reduced tissue elastance in OVA + ETS-challenged mice (p < 0.05; Mch 48 mg/ml) (b) and improved compliance (p < 0.001; Mch 48 mg/ml; ETS + OVA + ISS vs. ETS + OVA) (c).