Table 1.

CYP3A polymorphisms: previously observed effects

Polymorphism	Effects on gene transcription or antihypertensive drug pharmacokinetics
CYP3A5 A6986G	G-allele associations (also referenced as CYP3A5∗3C)
Ref SNP 776746	No differences in felodipine pharmacokinetics [17]
Intron-3	No significant differences in nifedipine metabolism [18]
CYP3A4 A–392G	G-allele associations (also referenced as CYP3A4∗1B)
Ref SNP 2740574	Increased gene transcription [30]
Promoter region	No significant effect on nifedipine metabolism [19]
CYP3A4 T16090C	C-allele associations
Ref SNP 2246709	Interaction with CYP2D6; higher metabolism of [26] and lower sympathetic activity from yohimbine [43]
Intron-7	No significant association with CYP3A4 enzyme activity [37, 44]