Baseline characteristics and outcomes stratified by gender or MAP group
AASK participant characteristic | All (n = 149) | Gender |
MAP group |
||||
---|---|---|---|---|---|---|---|
males (n = 82) | females (n = 67) | p | low MAP (≤92 mm Hg) (n = 75) | usual MAP (≤107 mm Hg) (n = 74) | p | ||
Number randomized to low MAP (%) | 75 (50) | 39 (52) | 36 (48) | – | – | ||
Number of men (%) | 82 (55) | – | – | 39 (52) | 43 (58) | ||
Number who did not reach target (%) | 11 (7) | 10 (12) | 1 (1.5) | 0.04 | 4 (5) | 7 (10) | 0.46 |
Age at randomization, years | 53 ± 11 | 52 ± 11 | 54 ± 11 | 0.27 | 53 ± 11 | 53 ± 11 | 0.93 |
Baseline MAP, mm Hg | 115 ± 18 | 117 ± 20 | 112 ± 15 | 0.05 | 116 ± 20 | 112 ± 15 | 0.13 |
Body mass index, kg/m2 | 31 ± 7 | 31 ± 6 | 30 ± 7 | 0.63 | 31 ± 6 | 31 ± 7 | 0.82 |
Serum creatinine, mg/dl | 2.05 ± 0.82 | 2.33 ± 0.89 | 1.70 ± 0.55 | <0.0001 | 1.94 ± 0.73 | 2.15 ± 0.89 | 0.13 |
Glomerular filtration rate, ml/min per 1.73 m2 | 46 ± 13 | 47 ± 13 | 45 ± 12 | 0.17 | 46 ± 12 | 46 ± 13 | 0.82 |
Total cholesterol, mg/dl | 214 ± 47 | 211 ± 48 | 217 ± 47 | 0.46 | 206 ± 39 | 222 ± 54 | 0.04 |
Average number of daily medications | 3.53 ± 1.25 | 3.81 ± 1.24 | 3.20 ± 1.19 | 0.005 | 3.89 ± 1.15 | 3.16 ± 1.25 | 0.0003 |
Average MAP in first year after randomization | 100 ± 7 | 102 ± 7 | 98 ± 5 | 0.003 | 96 ± 6 | 104 ± 5 | <0.0001 |
p < 0.05 bolded.