. Author manuscript; available in PMC: 2010 Apr 12.

Published in final edited form as: J Am Coll Cardiol. 2008 Jul 15;52(3):231–236. doi: 10.1016/j.jacc.2008.04.016

Table 3.

Incremental Value of Metabolic Syndrome, C Reactive Protein, Adipocytokines or Homeostasis Model Assessment of Insulin Resistance in Predicting Coronary Calcium Scores beyond Established Risk Factors

	Likelihood Ratio Test (χ2)
Variable Added to Model	Added to Full Model^§	Added to Full Model with CRP and MetS
Metabolic Syndrome	6.78^**	--
C Reactive Protein	2.05	--
Adiponectin	0.52	--
Adiponectin in men	3.56	--
Adiponectin in women	0.24	--
Resistin	1.69	--
Leptin	11.4^†	6.87^**
HOMA-IR	14.83^†	10.39^†
Interleukin-6	7.31^**	2.92
Soluble TNF Receptor 2	4.73^*	2.19

Tobit regression model of CAC data. All continuous variables were included in model as log transformed variables. Likelihood ratio test χ2 statistics and p values are reported for comparison of nested models when each metabolic variable was added to a full model containing established risk factors.

^§

Full Model includes age, gender, race, 10 year Framingham Risk Score, family history, exercise, and medications (asa, statin, ace inhibitor). HOMA_IR = homeostasis model assessment of insulin resistance; MetS = metabolic syndrome; TNF = tumor necrosis factor.

p<0.05

^**

p<0.01

^†

p<0.001.