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. 2009 Dec 15;468(5):1423–1427. doi: 10.1007/s11999-009-1193-z

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© The Association of Bone and Joint Surgeons® 2009

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Fig. 3A–D — (A) No abnormality is present in this normal rat knee (Stain, hematoxylin and eosin; original magnification, ×10), (B) or this normal rat knee (Stain, Safranin-O; original magnification, ×20). (C) The irregular surface of the joint cartilage and exposure of subchondral bone are evident in this monosodium iodoacetate (MIA) rat knee (Stain, hematoxylin and eosin; original magnification, ×10). (D) Ulceration and fibrillation of the cartilage with inflammatory cell infiltration are present in this MIA rat knee (Stain, Safranin-O; original magnification, ×20).