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Receiver operating characteristic (ROC) curves for evaluation of the diagnostic performance characteristics for the individual markers: EGFR (A), nuclear area (B), and N/C ratio (C). Using a logistic regression model the combined EGFR and cytomorphometry marker panel (D) is predicted to exhibit an AUC value of 0.94 with 97% sensitivity and 93% specificity for characterization of oral malignant and pre-malignant lesions.
