Table 1.
Gene regions tested in this study
| Candidate Gene Symbol | Candidate Gene Names | Chrom. Location |
|---|---|---|
| APOA2 | Apolipoprotein A-II | 1q21-q23 |
| APOA5 | Apolipoprotein A-V | 11q23 |
| APOBEC1 | Apolipoprotien B mRNA editing enzyme | 12p13.1 |
| APOC3, APOA1 | Apolipoprotein C-III, A-I | 11q23.1-q23.2 |
| APOC4, APOC2 | Apolipoprotein C-IV, C-II | 19q13.2 |
| APOE, APOC1 | Apolipoprotein E | 19q13.2 |
| BTLA | B and T lymphocyte associated | 3q13.2 |
| CCL5 (RANTES) | Chemokine ligand 5 | 17q11.2-q12 |
| CCR5 | Chemokine receptor 5 | 3p21 |
| CD180 | CD180 | 5q12 |
| CD209 (DCSIGN), CD209L | CD209, CD209L | 19p13 |
| CD28 | CD28 | 2q33 |
| CD80 | CD80 | 3q13.3-q21 |
| CD81 | CD81 | 11p15.5 |
| CD86 | CD86 | 3q21 |
| CHUK | Conserved helix-loop-helix ubiquitous kinase | 10q24-25 |
| CTLA4 | Cytotoxic T-lymphocyte associated protein 4 | 2q33 |
| DDX58 (RIG-I) | Dead box polypeptide 58 | 9p12 |
| DHX58 (LGP-2) | DEXH box polypeptide 58 | 17q21.2 |
| EIF2AK2 | Eukaryotic translation initiation factor 2-alpha kinase 2 |
2p22-p21 |
| HAVCR1 | Hepatitis A virus cellular receptor 1 (TIM-1) | 5q33.2 |
| HAVCR2 | Hepatitis A virus cellular receptor 2 (TIM-3) | 5q33.3 |
| HLAA | Major histocompatibility complex, class I A | 6p21.3 |
| HLAB | Major histocompatibility complex, class I B | 6p21.3 |
| HLAC | Major histocompatibility complex, class I C | 6p21.3 |
| ICAM1, ICAM4, ICAM5 | Intracellular adhesion molecule 1, 4 & 5 | 19p13.3-p13.2 |
| ICAM3 | Intracellular adhesion molecule 3 | 19p13.3-p13.2 |
| ICOS | Inducible T-cell costimulator | 2q33 |
| IFITM1 | Interferon induced transmembrane protein 1 | 11p15.5 |
| IFNA1,IFNA10,IFNA7,IFNA17 | Interferon-alpha 1, 10, 7, 17 | 9p22 |
| IFNA14 | Interferon-alpha 14 | 9p22 |
| IFNA2 | Interferon-alpha 2 | 9p22 |
| IFNA21 | Interferon-alpha 21 | 9p22 |
| IFNA5 | Interferon-alpha 5 | 9p22 |
| IFNA6 | Interferon-alpha 6 | 9p22 |
| IFNA8 | Interferon-alpha 8 | 9p22 |
| IFNAR1 | Interferon receptor 1 | 21q22.11 |
| IFNAR2 | interferon receptor 2 | 21q22.1 |
| IFNB1 | Interferon beta 1, fibroblast | 9p21 |
| IFNG | Interferon gamma | 12q14 |
| IFNGR1 | Interferon gamma receptor 1 | 6q23-24 |
| IFNW1 | Interferon omega 1 | 9p22 |
| IKBKB | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta |
8p11.2 |
| IL10RA | IL 10 receptor alpha | 11q2.3 |
| IL12A | IL-12A | 3q12-q13.2 |
| IL12B | IL-12B | 5q31.1-q33.1 |
| IL18BP | IL-18 binding precursor | 11q22.2-q22.3 |
| IL1RL1 | IL-1 receptor-like 1 | 2q12 |
| IL2 | IL-2 | 4q26-q27 |
| INDO | Indoleamine-pyrrole 2,3 dioxygenase | 8p12-p11 |
| INPP5D | Inositol polyphosphate-5-phosphatase | 2q37.1 |
| IRAK3 | Interleukin-1 receptor associated kinase 3 | 12q14.3 |
| IRF3 | Interferon regulatory factor 3 | 19q13.3-q13.4 |
| IRF7 | Interferon regulatory factor 7 | 11p15.5 |
| IRF9 | Interferon regulatory factor 9 | 14q11.2 |
| JAG1 | Jagged 1 | 20p12.1-p11.23 |
| LAG3 | Lymphocyte activation gene 3 | 12p13.32 |
| LILRA1-LILRA6 | Leukocyte, Ig-like receptor subfamily A, member 1 – 6 |
19q13.4 |
| LMB7 | Proteasome subunit, beta type 8 | 6p21.3 |
| LRP8 | Low density lipoprotein receptor-related protein 8 |
1p34 |
| MBL | Mannose binding lectin | 10q11.2-q21 |
| MX1, MX2 | Myxovirus resistance 1 and 2 | 21q22.3 |
| MYD88 | Myeloid differentiation primary response gene 88 |
3p22 |
| NFKB1 | Nuclear factor of kappa light polypeptide gene enhancer in B cells 1 |
4q24 |
| NOTCH4 | Notch homolog 4 | 6p21.3 |
| PIK3CA | Phosphoinositide-3-kinase catalytic, alpha polypeptide |
3q26.3 |
| PIK3CB | Phosphoinositide-3-kinase catalytic, beta polypeptide |
3q22.3 |
| PIK3CG | Phosphoinositide-3-kinase catalytic, gamma polypeptide |
7q22.3 |
| RNASEL | Ribonuclease L | 1q25 |
| SCARB1 | Scavenger receptor class B, member 1 | 12q24.31 |
| SIGIRR | Single immunoglobulin and toll-interleukin 1 receptor domain |
11p15.5 |
| SLC26A9 | Solute carrier family 26, member 9 | 1q31-q32 |
| SLC4A10 | Solute carrier family 4, sodium bicarbonate transporter-like, member 10 |
2q23-q24 |
| SOCS1 | Suppressor of cytokine signaling 1 | 16p13.3 |
| SP110 | SP110 nuclear body protein | 2q37.1 |
| STAT1 | Signal transducer and activator of transcription 1 |
2q32.2 |
| STAT2, APOF, IL23 | Signal transducer and activator of transcription 2, Apolipoprotein F, IL-23 |
12q13.2 |
| STAT3, STAT5A | Signal transducer and activator of transcription 3, 5A |
17q21.31 |
| TANK | TRAF family member-associated NFKB activator |
2q24-q31 |
| TBK1 | Tank binding kinase 1 | 12q14.1 |
| TICAM1 (TRIF) | Toll-like receptor adaptor molecule 1 | 19p13.3 |
| TLR3 | Toll-like receptor 3 | 4q35 |
| TLR9 | Toll-like receptor 9 | 3p21.3 |
| TNFA | TNF alpha | 6p21.3 |
| TNFRSF1A | TNF receptor superfamily, member 1 | 12p13.2 |
| TNFSFR18 (GITL), TNFRSF4 | TNF receptor superfamily, member 18, 4 | 1p36.3 |
| TNFSF18 (GITRL) | TNF ligand superfamily, member 18 | 1q23 |
| TNFSF4 | TNF ligand superfamily, member 4 | 1q25 |
| TRAF5 | TNF receptor-associated factor 5 | 1q32 |
| TRAF6 | TNF receptor associated factor 6 | 11p12 |
| TRAM1 | Translocation associated membrane protein 1 | 8q13.3 |
| TSG101 | Tumor susceptibility gene 101 | 11p15 |
| VDR | Vitamin D receptor | 12q13.11 |
Headings indicate the following information: Candidate Gene Symbol, official symbol of the tested candidate gene. If more than one candidate gene was tested in a region, both official symbols are listed. Symbols in parenthesis indicate a common alternate name; Candidate Gene Name, official full name of the tested candidate gene; Chromosome Region, location of the candidate gene region.