Table 4.
Empirical p-values of all SNPs tested in the TNFSF18, TANK, HAVCR1 and IL18BP Gene Regions
| Gene Region |
CHR | Position BP |
SNP | African-American empirical p-value |
European-American empirical p-value |
|---|---|---|---|---|---|
| TNFSF18 | 1 | 169736971 | rs12067458 | 0.43 | NA |
| TNFSF18 | 1 | 169744461 | rs6425201 | 0.33 | NA |
| TNFSF18 | 1 | 169745424 | rs975074 | 0.07 | 0.23 |
| TNFSF18 | 1 | 169749143 | rs2236876 | 0.11 | 0.004 (0.04) |
| TNFSF18 | 1 | 169749920 | rs723858 | 0.002 (0.03) | 0.02 |
| TNFSF18 | 1 | 169753006 | rs7537126 | 0.40 | NA |
| TNFSF18 | 1 | 169758508 | rs7546619 | 0.43 | 0.007 |
| TNFSF18 | 1 | 169764274 | rs957544 | 0.02 | 0.009 |
| TNFSF18 | 1 | 169768905 | rs2223517 | 0.17 | 0.30 |
| TANK | 2 | 161801194 | rs13430514 | 0.02 | 0.86 |
| TANK | 2 | 161803154 | rs2884364 | 0.66 | 0.77 |
| TANK | 2 | 161805389 | rs1267082 | 0.22 | 0.079 |
| TANK | 2 | 161810654 | rs4664406 | 0.02 | 0.86 |
| TANK | 2 | 161813607 | rs7586242 | 0.003 | NA |
| TANK | 2 | 161813990 | rs1267070 | 0.28 | 0.005(0.04) |
| TANK | 2 | 161820633 | rs3820998 | 0.007 | NA |
| TANK | 2 | 161828644 | rs13402291 | 0.05 | NA |
| TANK | 2 | 161837642 | rs1267068 | 0.05 | 0.07 |
| TANK | 2 | 161841338 | rs1559526 | 0.51 | 0.26 |
| TANK | 2 | 161844150 | rs1267059 | 0.12 | 0.0008 (0.004) |
| TANK | 2 | 161848350 | rs3769980 | 0.005 | NA |
| TANK | 2 | 161854620 | rs7568498 | NA | 0.79 |
| TANK | 2 | 161858169 | rs889916 | 0.39 | 0.002(0.03) |
| TANK | 2 | 161864079 | rs1267080 | 0.59 | 0.004(0.03) |
| TANK | 2 | 161873088 | rs1267072 | 0.05 | 0.07 |
| TANK | 2 | 161877080 | rs1267074 | 0.04 | 0.06 |
| TANK | 2 | 161882525 | rs3754972 | 0.005 | NA |
| TANK | 2 | 161889871 | rs10186736 | 0.02 | NA |
| TANK | 2 | 161898245 | rs1267034 | 0.02 | 0.04 |
| TANK | 2 | 161911654 | rs10189790 | 0.52 | NA |
| TANK | 2 | 161914481 | rs12471074 | 0.007 | NA |
| TANK | 2 | 161923662 | rs1267037 | 0.19 | 0.002 (0.01) |
| TANK | 2 | 161926585 | rs3820996 | 0.05 | NA |
| TANK | 2 | 161930291 | rs1146030 | 0.31 | 0.31 |
| TANK | 2 | 161932802 | rs3731769 | 0.53 | 0.37 |
| TANK | 2 | 161936739 | rs1267053 | 0.19 | NA |
| TANK | 2 | 161939567 | rs1882364 | 0.59 | 0.36 |
| HAVCR1 | 5 | 156369257 | rs1995377 | 0.08 | 0.79 |
| HAVCR1 | 5 | 156382326 | rs7707445 | 0.37 | 0.20 |
| HAVCR1 | 5 | 156390564 | rs6555810 | 0.91 | NA |
| HAVCR1 | 5 | 156392267 | rs7732478 | 0.89 | NA |
| HAVCR1 | 5 | 156392673 | rs2277025 | 0.80 | 0.06 |
| HAVCR1 | 5 | 156393018 | rs6880589 | 0.0007 (0.01) | NA |
| HAVCR1 | 5 | 156396820 | rs2036402 | 0.28 | 0.28 |
| HAVCR1 | 5 | 156402361 | rs2270926 | 0.53 | 0.14 |
| HAVCR1 | 5 | 156409978 | rs953569 | 0.14 | 0.007 |
| HAVCR1 | 5 | 156411901 | rs1553318 | 0.15 | 0.13 |
| HAVCR1 | 5 | 156412087 | rs1553316 | 0.10 | 0.86 |
| HAVCR1 | 5 | 156421481 | rs6873777 | 0.44 | 0.04 |
| HAVCR1 | 5 | 156423731 | rs4704843 | 0.47 | 0.04 |
| HAVCR1 | 5 | 156432559 | rs2116787 | 0.65 | 0.67 |
| HAVCR1 | 5 | 156436363 | rs7725390 | 0.06 | 0.25 |
| HAVCR1 | 5 | 156437811 | rs11134551 | 0.54 | 0.10 |
| IL18BP | 11 | 71367189 | rs6592455 | 0.90 | 1 |
| IL18BP | 11 | 71372293 | rs4945392 | 0.74 | NA |
| IL18BP | 11 | 71379171 | rs2276384 | 1.00 | NA |
| IL18BP | 11 | 71381789 | rs7124429 | 0.70 | NA |
| IL18BP | 11 | 71388126 | rs2298455 | 0.71 | 0.003 (0.004) |
| IL18BP | 11 | 71390101 | rs5743673 | 0.65 | NA |
| IL18BP | 11 | 71391681 | rs5743679 | 0.74 | NA |
| IL18BP | 11 | 71403860 | rs3750912 | 0.005 (0.04) | NA |
| IL18BP | 11 | 71405070 | rs1057992 | 0.76 | NA |
| IL18BP | 11 | 71407954 | rs949326 | 0.91 | NA |
| IL18BP | 11 | 71408363 | rs2298456 | 0.75 | 1 |
| IL18BP | 11 | 71411859 | rs2298457 | 0.75 | 1 |
Allelic association analysis with 25,000 permutations was performed on AA and EA data separately. Headings indicate the following information: Gene Region, gene region containing the tested SNP; CHR, chromosome where the tested SNP is located; Position, chromosomal position, in base pairs, of the tested SNP; SNP, rs number of the tested SNP. AA and EU Empirical P-value, empirical p-value of the tested SNPs in AA and EA populations. Italicized SNPs have empirical p-values < 0.01. Parenthesis denotes gene specific permuted p-values. NA indicates that the MAF was < 0.05 and a p-value was not calculated for this population