Table 4.
Allelic and Genotypic Association of NOD2 Single Nucleotide Polymorphisms with Erythema Nodosum Leprosum
| Allele | Genotype | Allelic Comparisons | Genotypic Comparisons |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| SNP,group | Gene | 0 | 1 | 00 | 01 | 11 | OR (95%CI) | PA | c2 (2df) | P |
| SNP type |
||||||||||
| rs7186262 | ||||||||||
| No RR | 394 (0.520) | 364 (0.480) | 99 (0.261) | 196 (0.517) | 84 (0.222) | |||||
| RR | 115 (0.513) | 109 (0.487) | 30 (0.268) | 55 (0.491) | 27 (0.241) | 0.97 (0.72-1.33) | 0.866 | 0.274 | 0.872 | |
| rs1109863 | ||||||||||
| No RR | 395 (0.506) | 385 (0.494) | 99 (0.261) | 197 (0.520) | 94 (0.248) | |||||
| RR | 124 (0.539) | 106 (0.461) | 35 (0.313) | 54 (0.482) | 26 (0.232) | 1.14 (0.84-1.55) | 0.383 | 1.163 | 0.559 | |
| rs12448797 | ||||||||||
| No RR | 719 (0.908) | 73 (0.092) | 331 (0.873) | 57 (0.150) | 8 (0.021) | |||||
| RR | 211 (0.894) | 25 (0.106) | 93 (0.830) | 25 (0.223) | 0 (0.000) | 0.86 (0.52-1.45) | 0.528 | 5.264 | 0.072 | |
| rs8059649 | ||||||||||
| No RR | 774 (0.965) | 28 (0.035) | 373 (0.984) | 28 (0.074) | 0 (0.000) | |||||
| RR | 224 (0.941) | 14 (0.059) | 105 (0.938) | 14 (0.125) | 0 (0.000) | 0.58 (0.29-1.21) | 0.100 | 2.827 | 0.093 | |
| rs12443880 | ||||||||||
| No RR | 763 (0.961) | 31 (0.039) | 368 (0.971) | 27 (0.071) | 2 (0.005) | |||||
| RR | 222 (0.965) | 8 (0.035) | 107 (0.955) | 8 (0.071) | 0 (0.000) | 1.13 (0.50-2.88) | 0.766 | 0.584 | 0.747 | |
| rs6596 | ||||||||||
| No RR | SLIC1 | 805 (0.984) | 13 (0.016) | 396 (1.045) | 13 (0.034) | 0 (0.000) | ||||
| RR | Syn | 237 (0.988) | 3 (0.013) | 117 (1.045) | 3 (0.027) | 0 (0.000) | 1.28 (0.35-7.03) | 0.705 | 0.146 | 0.703 |
| rs1131716 | ||||||||||
| No RR | SLIC1 | 765 (0.949) | 41 (0.051) | 363 (0.958) | 39 (0.103) | 1 (0.003) | ||||
| RR | NSyn | 223 (0.945) | 13 (0.055) | 105 (0.938) | 13 (0.116) | 0 (0.000) | 0.92 (0.47-1.90) | 0.797 | 0.469 | 0.791 |
| rs2287195 | ||||||||||
| No RR | SLIC1 | 466 (0.635) | 268 (0.365) | 154 (0.406) | 158 (0.417) | 55 (0.145) | ||||
| RR | Intron | 128 (0.587) | 90 (0.413) | 31 (0.277) | 66 (0.589) | 12 (0.107) | 0.82 (0.59-1.13) | 0.202 | 10.366 | 0.006 |
| rs8044354 | ||||||||||
| No RR | 443 (0.548) | 365 (0.452) | 125 (0.330) | 193 (0.509) | 86 (0.227) | |||||
| RR | 111 (0.474) | 123 (0.526) | 20 (0.179) | 71 (0.634) | 26 (0.232) | 0.74 (0.55-1.01) | 0.046 | 9.272 | 0.010 | |
| rs8043770 | ||||||||||
| No RR | 569 (0.706) | 237 (0.294) | 205 (0.541) | 159 (0.420) | 39 (0.103) | |||||
| RR | 158 (0.675) | 76 (0.325) | 50 (0.446) | 58 (0.518) | 9 (0.080) | 0.87 (0.63-1.20) | 0.367 | 3.835 | 0.147 | |
| rs10459815 | ||||||||||
| No RR | 746 (0.933) | 54 (0.068) | 350 (0.923) | 46 (0.121) | 4 (0.011) | |||||
| RR | 215 (0.919) | 19 (0.081) | 98 (0.875) | 19 (0.170) | 0 (0.000) | 0.82 (0.47-1.50) | 0.472 | 2.933 | 0.231 | |
| rs7194886 | ||||||||||
| No RR | 663 (0.813) | 153 (0.188) | 275 (0.726) | 113 (0.298) | 20 (0.053) | |||||
| RR | 180 (0.756) | 58 (0.244) | 66 (0.589) | 48 (0.429) | 5 (0.045) | 0.72 (0.50-1.03) | 0.057 | 6.943 | 0.031 | |
| rs2067085 | ||||||||||
| No RR | NOD2 | 674 (0.845) | 124 (0.155) | 289 (0.763) | 96 (0.253) | 14 (0.037) | ||||
| RR | Syn | 186 (0.802) | 46 (0.198) | 74 (0.661) | 38 (0.339) | 4 (0.036) | 0.74 (0.50-1.11) | 0.121 | 3.566 | 0.168 |
| rs6500328 | ||||||||||
| No RR | NOD2 | 607 (0.778) | 173 (0.222) | 239 (0.631) | 129 (0.340) | 22 (0.058) | ||||
| RR | Intron | 170 (0.720) | 66 (0.280) | 57 (0.509) | 56 (0.500) | 5 (0.045) | 0.73 (0.52-1.04) | 0.066 | 8.098 | 0.017 |
| rs13339578 | ||||||||||
| No RR | NOD2 | 520 (0.679) | 246 (0.321) | 173 (0.456) | 174 (0.459) | 36 (0.095) | ||||
| RR | Intron | 146 (0.646) | 80 (0.354) | 41 (0.366) | 64 (0.571) | 8 (0.071) | 0.86 (0.63-1.20) | 0.356 | 4.410 | 0.110 |
| rs17312836 | ||||||||||
| No RR | NOD2 | 640 (0.804) | 156 (0.196) | 260 (0.686) | 120 (0.317) | 18 (0.047) | ||||
| RR | Intron | 172 (0.741) | 60 (0.259) | 61 (0.545) | 50 (0.446) | 5 (0.045) | 0.70 (0.49-1.00) | 0.039 | 6.900 | 0.032 |
| rs1861759 | ||||||||||
| No RR | NOD2 | 650 (0.797) | 166 (0.203) | 261 (0.689) | 128 (0.338) | 19 (0.050) | ||||
| RR | Syn | 176 (0.733) | 64 (0.267) | 60 (0.536) | 56 (0.500) | 4 (0.036) | 0.70 (0.50-1.00) | 0.037 | 9.574 | 0.008 |
| rs4785225 | ||||||||||
| No RR | NOD2 | 564 (0.683) | 262 (0.317) | 190 (0.501) | 184 (0.485) | 39 (0.103) | ||||
| RR | Intron | 157 (0.654) | 83 (0.346) | 45 (0.402) | 67 (0.598) | 8 (0.071) | 0.88 (0.64-1.21) | 0.404 | 4.851 | 0.088 |
| rs17313265 | ||||||||||
| No RR | NOD2 | 676 (0.873) | 98 (0.127) | 299 (0.789) | 78 (0.206) | 10 (0.026) | ||||
| RR | Intron | 211 (0.917) | 19 (0.083) | 96 (0.857) | 19 (0.170) | 0 (0.000) | 1.61 (0.95-2.85) | 0.068 | 4.013 | 0.134 |
| rs751271 | ||||||||||
| No RR | NOD2 | 567 (0.688) | 257 (0.312) | 195 (0.515) | 177 (0.467) | 40 (0.106) | ||||
| RR | Intron | 156 (0.655) | 82 (0.345) | 45 (0.402) | 66 (0.589) | 8 (0.071) | 0.86 (0.63-1.19) | 0.341 | 5.913 | 0.052 |
| rs1861758 | ||||||||||
| No RR | NOD2 | 604 (0.791) | 160 (0.209) | 240 (0.633) | 124 (0.327) | 18 (0.047) | ||||
| RR | Intron | 169 (0.728) | 63 (0.272) | 58 (0.518) | 53 (0.473) | 5 (0.045) | 0.71 (0.50-1.01) | 0.047 | 6.859 | 0.032 |
| rs5743289 | ||||||||||
| No RR | NOD2 | 803 (0.984) | 13 (0.016) | 395 (1.042) | 13 (0.034) | 0 (0.000) | ||||
| RR | Intron | 234 (0.983) | 4 (0.017) | 115 (1.027) | 4 (0.036) | 0 (0.000) | 0.95 (0.29-4.03) | 0.925 | 0.009 | 0.924 |
| rs5743291 | ||||||||||
| No RR | NOD2 | 751 (0.978) | 17 (0.022) | 368 (0.971) | 15 (0.040) | 1 (0.003) | ||||
| RR | NSyn | 230 (0.983) | 4 (0.017) | 113 (1.009) | 4 (0.036) | 0 (0.000) | 1.30 (0.42-5.37) | 0.637 | 0.366 | 0.833 |
| rs3135499 | ||||||||||
| No RR | NOD2 | 627 (0.768) | 189 (0.232) | 240 (0.633) | 147 (0.388) | 21 (0.055) | ||||
| RR | 3′UTR | 171 (0.718) | 67 (0.282) | 58 (0.518) | 55 (0.491) | 6 (0.054) | 0.77 (0.55-1.08) | 0.114 | 4.154 | 0.125 |
| rs3135500 | ||||||||||
| No RR | NOD2 | 588 (0.776) | 170 (0.224) | 230 (0.607) | 128 (0.338) | 21 (0.055) | ||||
| RR | 3′UTR | 166 (0.735) | 60 (0.265) | 59 (0.527) | 48 (0.429) | 6 (0.054) | 0.80 (0.56-1.15) | 0.199 | 2.916 | 0.233 |
| rs8056611 | ||||||||||
| No RR | 450 (0.568) | 342 (0.432) | 137 (0.361) | 176 (0.464) | 83 (0.219) | |||||
| RR | 126 (0.525) | 114 (0.475) | 32 (0.286) | 62 (0.554) | 26 (0.232) | 0.84 (0.62-1.13) | 0.238 | 2.831 | 0.243 | |
| rs751919 | ||||||||||
| No RR | 596 (0.766) | 182 (0.234) | 231 (0.609) | 134 (0.354) | 24 (0.063) | |||||
| RR | 165 (0.730) | 61 (0.270) | 58 (0.518) | 49 (0.438) | 6 (0.054) | 0.83 (0.58-1.18) | 0.266 | 3.005 | 0.223 | |
| rs11862720 | ||||||||||
| No RR | CYLD | 612 (0.799) | 154 (0.201) | 242 (0.639) | 128 (0.338) | 13 (0.034) | ||||
| RR | Intron | 186 (0.809) | 44 (0.191) | 72 (0.643) | 42 (0.375) | 1 (0.009) | 1.06 (0.72-1.58) | 0.745 | 2.259 | 0.323 |
| rs1477176 | ||||||||||
| No RR | CYLD | 704 (0.936) | 48 (0.064) | 329 (0.868) | 46 (0.121) | 1 (0.003) | ||||
| RR | Intron | 219 (0.952) | 11 (0.048) | 104 (0.929) | 11 (0.098) | 0 (0.000) | 1.36 (0.68-2.95) | 0.371 | 0.932 | 0.627 |
| rs9925070 | ||||||||||
| No RR | CYLD | 632 (0.790) | 168 (0.210) | 252 (0.665) | 128 (0.338) | 20 (0.053) | ||||
| RR | Intron | 180 (0.756) | 58 (0.244) | 65 (0.580) | 50 (0.446) | 4 (0.036) | 0.82 (0.58-1.18) | 0.269 | 4.270 | 0.118 |
| rs1420872 | ||||||||||
| No RR | CYLD | 587 (0.789) | 157 (0.211) | 230 (0.607) | 127 (0.335) | 15 (0.040) | ||||
| RR | Intron | 174 (0.770) | 52 (0.230) | 66 (0.589) | 42 (0.375) | 5 (0.045) | 0.89 (0.62-1.31) | 0.541 | 0.427 | 0.808 |
| rs2302759 | ||||||||||
| No RR | CYLD | 521 (0.651) | 279 (0.349) | 180 (0.475) | 161 (0.425) | 59 (0.156) | ||||
| RR | Intron | 156 (0.661) | 80 (0.339) | 50 (0.446) | 56 (0.500) | 12 (0.107) | 1.04 (0.76-1.44) | 0.782 | 2.666 | 0.264 |
A
P values in bold are less than 0.05 for the allelic and genotypic analyses