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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Pediatr Res. 2010 Mar;67(3):293–299. doi: 10.1203/PDR.0b013e3181cb8e68

Table 4.

Neurobehavioral findings in infants, children, adolescents, and young adults comparing apoE4+ versus apoE4-.

Age Outcome Reference
2 apoE4+ > apoE4- on Bayley Scale of Infant Development 26
6-15 apoE4+ = apoE4- on IQ 6
7-9 apoE4+ < apoE4- on spatial memory of Memory Island present study
8-20 apoE4+ < apoE4- on entorhinal cortical thickness 24
8-16 apoE4 × health interaction on visual memory 15
11 apoE4+ = apoE4- on verbal and non-verbal reasoning 22
11-16 apoE4 < apoE2 on Rey- Osterrieth Complex Figure Test (ROCFT) 20
11-16 apoE4 × Alzheimer's family history interaction on and ROCFT 21
11-16 apoE4 × Alzheimer's family history interaction on reading and language 21
16-30 apoE4 < apoE3 on navigating through a computerized grid maze 17
19-21 apoE4+ > apoE4- on performance IQ 37
20-35 apoE4+ > apoE4- on hippocampal activity during memory encoding 47
22 apoE4+ > apoE4- on verbal delayed recall 19

>: better performance (higher percent correct, faster reaction time, fewer trials to criterion), <: worse performance (lower percent correct, slower reaction time, more trials to criterion).