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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Nat Rev Neurosci. 2009 Jul 8;10(8):597–609. doi: 10.1038/nrn2670

Figure 2B. Domains of SMN.

Figure 2B

A diagram of SMN showing the exons and domains. Exon 2B encodes a domain important in binding Gemin2 as well as self-association.160 Both exon 2A and 2B are conserved. The K domain is rich in lysine, the Tudor domain is in exon 3 and has homology to other Tudor domains. The Tudor domain binds Sm proteins.97 Exon 5 and part of exon 6 contain a proline rich domain that may influence profilin binding.161 The C-terminal domain of exon 6 contains the conserved YG box and is important for self-association.160, 162