. Author manuscript; available in PMC: 2010 Apr 13.

Published in final edited form as: Harv Rev Psychiatry. 2002 Nov–Dec;10(6):324–336. doi: 10.1080/10673220216231

TABLE 4. Neurodevelopmental Studies Utilizing DTI.

Study	n	Measure(s)	Findings^*
Hüppi et al.³	24 infants: 17 preterm, 7 full-term	Diffusivity, RA	Anisotropy was higher the closer birth was to term
Klingberg et al.⁹¹	7 children, 5 adults	FA, Tr	Anisotropy in frontal white matter was lower in children than in adults
Pfefferbaum et al.⁷¹	31 healthy men, ages 23–76 y	Diffusivity, FA, IC	Anisotropy declined with age in all regions except the splenium of the corpus callosum
Nusbaum et al.⁹²	20 healthy volunteers, ages 20–91 y	RA, diffusivity histograms	Anisotropy decreased significantly with increasing age in periventricular white matter, frontal white matter, and the genu and splenium of the corpus callosum

FA, fractional anisotropy; IC, intervoxel coherence; RA, relative anisotropy; Tr, diffusion trace.

All findings reported are significant at p ≤ 0.05.