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. Author manuscript; available in PMC: 2010 Apr 23.
Published in final edited form as: Circ Res. 2009 Sep 10;105(9):921–929. doi: 10.1161/CIRCRESAHA.109.200279

Figure 2. Cleavage of Ang I by MMP8, producing Ang II and Ang1-7.

Figure 2

Panel A: Chromatogram of mass spectrometry analysis of uncleaved Ang I, showing the detection of Ang I peptide ion (m/z value 432.84 3+). Panel B: Chromatogram of mass spectrometry analysis of products of Ang I cleavage by MMP8, showing the presence of Ang II (m/z value 523.79 2+) and Ang1-7 (450.25 2+) peptide ions, in addition to Ang I (m/z value 432.91 3+). The presence of Ang II, Ang1-7 and Ang I in the respective peaks were confirmed by peptide fragmentation sequencing.