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. Author manuscript; available in PMC: 2010 Apr 23.
Published in final edited form as: Circ Res. 2009 Sep 10;105(9):921–929. doi: 10.1161/CIRCRESAHA.109.200279

Table 1. Association between MMP8 gene variation and extent of coronary atherosclerosis in patients with coronary artery disease (n=2000).

rs1940475 SNP Subjects with
significant atherosclerosis*
in one coronary artery		 Subjects with
significant atherosclerosis*
in two or three coronary arteries		 Odds ratio (95% confidence interval) †
for significant atherosclerosis*
in two or three coronary arteries
Genotype n (%) n (%)
C/C 170 (22.2) 342 (27.7) reference
C/T 398 (52.0) 632 (51.2) 0.77 (0.62-0.97), p=0.028
T/T 198 (25.8) 260 (21.1) 0.63 (0.49-0.83), p=0.0008
Total 766 (100.0) 1234 (100.0)
Allele frequency frequency
C 0.48 0.53 reference
T 0.52 0.47 0.80 (0.70-0.91), p=0.0008
*

Signifcant atherosclerosis was defined by >50% stenosis.

†

calculated by logistic regression analysis with adjustment for age, gender, smoking, hypercholesterolemia, hypertension and diabetes.