Figure 6.

Schistosoma mansoni development in recombination activating gene (RAG)–1–deficient (RAG-1^−/−) mice reconstituted with interleukin (IL)–2^−/− or wild-type CD4⁺ T cells. One day before infection, RAG-1^−/− recipients were reconstituted with 4 × 10⁶ CD4⁺ T cells from wild-type (IL-2^+/+) or IL-2^−/− donors, and S. mansoni worm development and egg production were assessed at 6 weeks after infection. A, Length of male S. mansoni worms isolated from RAG-1^−/− recipients reconstituted with PBS alone, IL-2^+/+ CD4⁺ T cells, or IL-2^−/− CD4⁺ T cells); overall P <.0001, Kruskal-Wallis test. B, Percentage of female worms participating in pairs in RAG-1^−/− recipients reconstituted with PBS alone, IL-2^+/+ CD4⁺ T cells, or IL-2^−/− CD4⁺ T cells; overall P = .5833, Kruskal-Wallis test. C, No. of eggs deposited per pair of worms in the livers of RAG-1^−/− recipients reconstituted with PBS alone, IL-2^+/+ CD4⁺ T cells, or IL-2^−/− CD4⁺ T cells; overall P = .0474, Kruskal-Wallis test. In panels A, B, and C, P values for each experimental group pair were calculated using Dunn’s multiple comparison test.