Table 1.
Recovery of HIV from Resting CD4+ T Cells Isolated from Aviremic, ART-Treated, HIV-Infected Individuals after Exposure to SAHA, VPA, or Maximal Mitogen Activation
|
Infected units per billion of HIV+ donor resting CD4+ T cells expressing HIV after exposure to HDAC inhibitor or mitogen | |||
|---|---|---|---|
| Patients | SAHA (250–335 nM) | VPA (40 μM) | Maximal mitogena |
| 1visit A | 3560 | >3560 | 17950 |
| 1visit B | 4540 | 3220 | 11340 |
| 2 | 543 | 703 | 1243 |
| 3visit A | 561 | Not done | 487 |
| 3visit B | 410 | 223 | 440 |
| 4 | 280 | 179b | 426 |
| 5 | Not recoveredc | Not recovered | 45 |
a
PHA 1 μg/ml, IL2 100 U/ml, 5-fold excess irradiated allogeneic cells.
b
Frequency of HIV outgrowth not above background (IL-2 only control).
c
Patients 1 and 2: 335 nM; patients 3–5: 250 nM.