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. Author manuscript; available in PMC: 2011 Apr 16.
Published in final edited form as: Org Lett. 2010 Apr 16;12(8):1792–1795. doi: 10.1021/ol100418n

Table 1.

IC50 (nM) values of spongistatin 1 and analogs in the cell growth inhibition assay with different cancer cell lines.

MDA-MB-435 HT-29 H522-T1 U937
(+)-Spongistatin 1 0.0225 0.058 0.16 0.059
(+)-9 >1000 >1000 >1000 >1000
(−)-10 82.8 161.2 297.2 60.5