Table 4.
Changes at D5S346 and D17S250 in 5-ASA- (n = 25; 100 biopsies) and EcN- (n = 14; 56 biopsies) treated patients
| Subset | 5-ASA % (n) |
D5S346 |
D17S250 |
Any Group % (n) |
|||
|---|---|---|---|---|---|---|---|
| EcN % (n) | Any Group % (n) | 5-ASA % (n) | EcN % (n) | ||||
| Non-informative | 28 (7) | 36 (5) | 33 (12) | 56 (14) | 43 (6) | 51 (20) | |
| Improvement | MSI-MSS | 4 (1) | 14 (2) | 8 (3) | 8 (2) | 7 (1) | 8 (3) |
| LOH-MSS | 4 (1) | 7 (1) | 5 (2) | 4 (1) | 0 (0) | 3 (1) | |
| Worsening | MSS-MSI | 16 (4)* | 0 (0) | 10 (4)* | 8 (2) | 0 (0) | 5 (2) |
| MSS-LOH | 12 (3)* | 0 (0) | 8 (3)* | 0 (0) | 14 (2) | 5 (2) | |
| No change | MSS-MSS | 32 (8) | 29 (4) | 33 (12) | 20 (5) | 7 (1) | 15 (6) |
| MSI-MSI | 8 (2) | 7 (1) | 8 (3) | 4 (1) | 14 (2) | 8 (3) | |
| LOH-LOH | 4 (1) | 0 (0) | 3 (1) | 0 (0) | 7 (1) | 3 (1) | |
| Indifferent | MSI-LOH | 0 (0) | 7 (1) | 3 (1) | 0 (0) | 7 (1) | 3 (1) |
| LOH-MSI | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |
*
Two patients showed overlapping MSI and LOH events; therefore, the percent change and total number of patients (n) reflect a deviation from expected values.