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. Author manuscript; available in PMC: 2010 Apr 13.
Published in final edited form as: Int J Biochem Cell Biol. 2009 Sep 9;41(12):2376–2379. doi: 10.1016/j.biocel.2009.09.004

Fig. 2.

Fig. 2

Schematic representation of the signal transduction initiated by cytokine receptors through JAK3. The heterodimeric IL7 receptor is used as an example. Conformational changes resulting from the binding of the cytokine to its receptor induce autophosphorylation of JAK3 and phosphorylation of the cytokine receptor by JAK3, which lead to recruitment of STAT and adaptor proteins that are then phosphorylated by JAK3 and other JAKs. Phosphorylated STAT factors migrate to the nucleus where they act as transcription factors of genes important for survival, proliferation and differentiation of lymphoid cells.