TABLE 3.

Maxima of regions showing significant age-adjusted relationship between IMT and rCBF in men and women

		Primary Correlation Analysis Adjusted for age						Primary Correlation Analysis Adjusted for age and MAP
Cluster Maxima*†	Side	Coordinates			T- value	p- value	Spatial Extent	Coordinates			T- value	p value	Spatial Extent
		x	y	z			(# voxels)	x	y	z			(# voxels)
Males: ↑ IMT ↓ rCBF
Superior temporal gyrus (BA 38)	R	46	18	−20	3.37	0.001	143	48	18	−22	3.7	<0.001	179
Males: ↑ IMT ↑ rCBF
Putamen	R	32	−14	0	4.06	<0.001	140	32	−14	0	4.02	<0.001	141
Inferior frontal gyrus (BA 47)	R	30	26	−16	3.51	0.001	112	30	26	−18	3.87	<0.001	138
Females: ↑ IMT ↓ rCBF
Middle temporal gyrus (BA 19)	R	34	−64	18	7.36	<0.001	4671	34	−64	18	5.77	<0.001	1297
Middle occipital gyrus (BA 19)	L	−38	−62	−2	4.92	<0.001	1509	−38	−62	−2	3.41	0.001	100
Inferior parietal lobule (BA 40)	R	64	−32	40	3.94	<0.001	369	-	-	-	-	-	-
Fusiform gyrus (BA 37)	L	−46	−48	−12	3.6	0.001	1534	−46	−48	−12	3.83	<0.001	112
Fusiform gyrus (BA 21)	L	-	-	-	-	-	-	−42	−8	−26	4.24	<0.001	159
Middle temporal gyrus (BA 21)	R	-	-	-	-	-	-	42	0	−16	3.64	0.001	237
Females: ↑ IMT ↑ rCBF
Medial frontal gyrus (BA 10)	L	−6	54	−6	5.01	<0.001	7325	−24	40	38	5.36	<0.001	6083
Superior temporal gyrus (BA 42)	L	−48	−28	18	4.43	<0.001	280	−48	−30	18	5.51	<0.001	807
Insula	R	36	−8	0	4.31	<0.001	489	30	0	8	3.37	0.001	157
Middle frontal gyrus (BA 8)	R	-	-	-	-	-	-	26	38	46	4.51	<0.001	148
Medial frontal gyrus (BA 6)	L	-	-	-	-	-	-	−6	14	44	3.51	0.001	165

^*Brodmann Areas noted in parenthesis.

^†All analyses are adjusted for the combined grey and white matter volume of a given region in which IMT is related to rCBF.