Table 1.
COMPARATIVE PROPERTIES OF FIV AND HIV
| FIV | HIV | |
|---|---|---|
| Transmission | ||
| -blood contact | + | + |
| -mucosal contact | + | + |
| Target cell | ||
| CD4+ T cell | + | + |
| Macrophage | + | + |
| Dentritic cell, | + | + |
| Subset B cells | + | ? |
| Microglia | + | + |
| Disease symptoms: | ||
| Oral lesions | + | + |
| Lymphadenopathy | + | + |
| Neutropenia | + | + |
| CD4 T cell depletion | + | + |
| Hypergammaglobulinemia | + | + |
| Wasting, diahrrea | + | + |
| Secondary infections | + | + |
| CNS lesions | + | + |
| Viral genes encoded | ||
| Gag,Pol,Env,LTRs | + | + |
| Vif | + | + |
| Rev/RRE | + | + |
| Tat/TAR | − | + |
| Vpr | − | + |
| Vpu | − | + |
| OrfA | + | − |
| DU | + | − |
| Receptors utilized | ||
| -primary binding receptor | ||
| CD4 | − | + |
| CD134 | + | − |
| Heparans | + | + |
| -entry receptor | ||
| CXCR4 | + | + |
| CCR5 | − | + |
| -other chemokine receptors | ? | + |