Table 3.

Metabolite ratios of MHE and control subjects.

Metabolite ratios	MHE		Controls		P values
	Frontal (Mean ± SD) [A]	Occipital (Mean ± SD) [B]	Frontal (Mean ± SD) [C]	Occipital (Mean ± SD) [D]	[A] vs [C]	[B] vs [D]
Ch_d/Cr_d	0.786 ± 0.142	0.697 ± 0.168	1.001 ± 0.082	0.954 ± 0.092	0.002	0.002
NAA_d/Cr_d	1.612 ± 0.119	1.445 ± 0.141	1.716 ± 0.157	1.624 ± 0.100	0.152	0.009
mICh/Cr_d	0.064 ± 0.019	0.058 ± 0.024	0.112 ± 0.011	0.117 ± 0.022	0.000	0.000
Asp/Cr_d	0.023 ± 0.007	0.028 ± 0.006	0.025 ± 0.004	0.025 ± 0.005	0.603	0.294
Cr/Cr_d	0.012 ± 0.006	0.017 ± 0.006	0.014 ± 0.002	0.014 ± 0.004	0.360	0.289
Glx/Cr_d	0.148 ± 0.034	0.178 ± 0.062	0.120 ± 0.016	0.116 ± 0.014	0.029	0.011
mI/Cr_d	0.011 ± 0.005	0.013 ± 0.005	0.022 ± 0.004	0.020 ± 0.005	0.000	0.017
NAA/Cr_d	0.308 ± 0.081	0.271 ± 0.076	0.321 ± 0.028	0.304 ± 0.052	0.653	0.314
Tau/Cr_d	0.007 ± 0.002	0.007 ± 0.003	0.011 ± 0.002	0.009 ± 0.003	0.016	0.347
PCh/Cr_d	0.007 ± 0.003	0.008 ± 0.003	0.007 ± 0.002	0.007 ± 0.002	0.817	0.639
GABA/Cr_d	0.007 ± 0.002	0.007 ± 0.004	0.006 ± 0.003	0.007 ± 0.003	0.757	0.829
PE/Cr_d	0.005 ± 0.002	0.005 ± 0.003	0.007 ± 0.002	0.005 ± 0.001	0.095	0.638
ThrLac/Cr_d	0.012 ± 0.005	0.011 ± 0.003	0.011 ± 0.002	0.015 ± 0.009	0.456	0.259

Cr_d, diagonal creatine; Ch_d, diagonal choline; NAA_d, diagonal N-acetyl aspartate; mICh, overlapping cross peak of myo-inositol and choline; Asp, aspartate; Glx, glutamate/glutamine; mI, myo-inositol; Tau, taurine; PCh, phosphocholine; GABA, gamma-aminobutyric acid; PE, phosphoethanolamine; ThrLac, overlapping cross peaks of threonine and lactate.