Table 5.

Energetics derived from thermal denaturation curves of duplexes between N2'-pyrene-functionalized 2'-amino-α-L-LNA and DNA/RNA.^a

		Complementary DNA			Complementary RNA
ON	Sequence	ΔG298 [ΔΔG298] (kJ/mol)	ΔH [ΔΔH] (kJ/mol)	T298ΔS [Δ(T298ΔS)] (kJ/mol)	ΔG298 [ΔΔG298] (kJ/mol)	ΔH [ΔΔH] (kJ/mol)	T298ΔS [Δ(T298ΔS)] (kJ/mol)
D1	5′-GTG ATA TGC	–41	–327	–286	–38	–275	–237
W2	5′-GTG AWA TGC	–53 [–12]	–307 [+20]	–254 [+32]	–44 [–6]	–328 [–53]	–284 [–47]
X2	5′-GTG AXA TGC	–59 [–18]	–348 [–21]	–289 [–3]	–49 [–11]	–343 [–68]	–294 [–57]
Y2	5′-GTG AYA TGC	–54 [–13]	–321 [+6]	–267 [+19]	–48 [–10]	–333 [–58]	–285 [–48]
Z2	5′-GTG AZA TGC	–46 [–5]	–336 [–9]	–290 [–4]	ND	ND	ND

^aSee Table 4 for conditions.