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. 2010 Feb 3;30(5):1914–1924. doi: 10.1523/JNEUROSCI.5485-09.2010

Figure 4.

Figure 4.

The reducing agent DTT increases NMDAR-mediated synaptic responses to a greater extent in aged than in the young animals. A, Time course of the change in the normalized NMDAR-fEPSP slope in the aged (filled circles) (n = 16) and young (open circles) (n = 5) animals following application of DTT for 45 min. Inset, Representative traces (average of 5 consecutive traces under each condition) illustrating the change in NMDAR-fEPSP in the presence of DTT in an aged (top) and a young animal. Calibration: 10 ms, 0.5 mV. B, Time course of the change in the normalized NMDAR-fEPSP slope in aged animals (filled circles) (n = 5) upon application of DTT for 45 min followed by a washout for 45 min.