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. Author manuscript; available in PMC: 2010 Apr 13.
Published in final edited form as: Cell. 2008 Nov 28;135(5):907–918. doi: 10.1016/j.cell.2008.10.025

Figure 3.

Figure 3

Transcriptional deregulation of SIRT1-associated genes in response to oxidative stress is repressed by increasing SIRT1 levels. (A) SIRT1 expression in wild-type (WT) and SIRT1 overexpressing (OE) ES cells. (B) q-RT-PCR analysis of putative SIRT1 target genes (SIRT1-bound), non-SIRT1-bound control genes and β-actin in wild-type (open bars) and SIRT1 overexpressing ES cells (closed bars). Shown is the fold change of expression compared to untreated samples. Data are represented as mean +/− SEM.