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H&E staining of sclerosing epithelioid fibrosarcoma after treatment with neoadjuvant chemotherapy (magnification ×400). The tumor is composed of few scattered polynuclear giant cells (black arrow) and groups of cells, which are rich in cytoplasm and show pale, vesicular, and irregular nuclei without any substantial mitotic activity (white arrow). The tumor cells are embedded in a collagen-rich extracellular matrix and display no signs of regression.
