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. Author manuscript; available in PMC: 2010 Apr 13.
Published in final edited form as: Opt Lett. 2009 Dec 15;34(24):3899–3901. doi: 10.1364/OL.34.003899

Figure 3.

Figure 3

(Color online) In vivo brain imaging of a Congo-red-injected 10-month-old APP/PS1 mouse through a cranial window. (A) The exposed cortical brain region imaged using conventional fluorescence microscopy through the cranial window. The region of interest marked by a red dashed box was imaged by (B) multiphoton microscopy, and optical-resolution photoacoustic microscopy at (C) 570 nm and (D) 523 nm, respectively. (E) The processed dual-contrast optical-resolution photoacoustic microscopic image, where amyloid plaques are colored green and blood vessels are colored red (volumetric visualization is available online as Media 1). Arrows: plaques. Scale bar in (B) applies for (B–E).