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IC50 values for PDE inhibitors against PDE7A and PDE7B
| Inhibitor IC50 (μM) | ||||
|---|---|---|---|---|
| Enzyme | BRL50481 | BC30 | BC11 | BC39 |
| PDE7A | 0.15 | 1.1 | 3.2 | 3.8 |
| PDE7B | 12.1 | 3.7 | 26.3 | 26.6 |
In vitro enzyme assays were carried out as described in the Materials and Methods. IC50 values were determined by linear interpolation using the three concentrations that resulted in the closest to 50% inhibition from a series of assays testing 8-9 inhibitor concentrations.
