Figure 2.

A single-nucleotide polymorphism (a guanine-to-adenine substitution) in the gene encoding the rat GABA_A receptor α6 subunit (Gabra6) is common in Sprague-Dawley rats obtained from Charles River Laboratories. Shown from left to right are the sequence chromatograms from a homozygous Gabra6^100R/100R, a heterozygous Gabra6^100R/100Q and a homozygous Gabra6^100Q/100Q rat. The lower panel shows the sequence of each Gabra6 genotype along with the corresponding amino acid translation (bottom). Gray boxes denote the codon for amino acid position 100.