Figure 4.

Tonic GABA current in granule cells is enhanced by low concentrations of ethanol in Gabra6^100R/100R and Gabra6^100Q/100Q rats. (a,b) Tonic currents recorded from Gabra6^100R/100R (a) or Gabra6^100Q/100Q (b) granule cells showing that 10 mM ethanol enhances the tonic current in the continuous presence of 300 nM GABA, TTX, NBQX and NO-711. (c) Summary data indicating that in response to 10 mM ethanol, significant increases in tonic current are observed in Gabra6^100R/100R granule cells (P < 0.05, n = 4) and larger enhancements are found in Gabra6^100Q/100Q granule cells (P < 0.05, n = 4).