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. 2010 Apr 13;4(4):e658. doi: 10.1371/journal.pntd.0000658

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Jackson et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A single segment in T. b. gambiense comprising three coding sequences (Tbg972.9.4160, 4140 and 4130) corresponds to a three-gene segmental duplication (5 repeats) on chromosome 9 in T. b. brucei. The first coding sequence (shaded red) is a conserved, hypothetical gene encoding a putative secretory protein and all copies are identical. The second (shaded yellow) and third (shaded orange) coding sequences are tandem-duplicate, conserved hypothetical genes encoding putative membrane-bound proteins. Both second and third genes contain substantial sequence variation in T. b. brucei; the upstream-most copies are orthologous to the T. b. gambiense genes, but none of the remaining variants were identified among T. b. gambiense sequence reads. The segmental duplication is preceded immediately upstream by an INGI-mediated insertion (shaded purple).