. 2010 Apr 13;4(4):e659. doi: 10.1371/journal.pntd.0000659

Table 2. Comparison of structural similarities of HTS hits to licensed compounds used against HAT and to known TbHK1 inhibitors.

Compound	Proposed Mode of Antiparasitic Action¹	TbHK1 Inhibitor (SID)	Similarity Coefficient²(%)
Pentamidine	Accumulation in the mitochondria, DNA binding	17386310	31
Suramin	Inhibition of glycolysis	24830882	38
		24797131	38
Melarsoprol	Inhibition of glycolysis Interaction with thiols	24830882	43
Eflornithine	Polyamine biosynthesis (via inhibition of ODC)	14728414	27
Lonidamine	TbHK1 inhibitor³	16952891	47
Quercetin	TbHK1 inhibitor⁴	24797131	38

Reviewed in [13].

Similarity coefficient was determined using the Tanimoto coefficient. Compounds with values greater than 80% are considered highly structurally similar.

[4].

⁴

Lyda and Morris, unpublished.