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. 2010 Apr 13;5(4):e10129. doi: 10.1371/journal.pone.0010129

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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For clarity the water molecules that bridge the interaction between Asp370 and the ketone oxygen atom are not displayed, but these water molecules along with other active-site water molecules are included in the coordinates of Datasets S1 and S2.