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. 2010 Apr 13;5(4):e10153. doi: 10.1371/journal.pone.0010153

Table 3. The 50 genes most distant to the origin of the coordinates space Inline graphic×Inline graphic.

Probe Set ID Gene Symbol Gene Title δ(sqrtJSD (P,Pc)) δ(sqrtJSD (P,Ps)) Dist O Ref (ADG)
206481_s_at LDB2 LIM domain binding 2 −0.7988 0.7427 1.0907
219736_at TRIM36 tripartite motif-containing 36 −0.8077 0.7242 1.0848
200650_s_at LDHA lactate dehydrogenase A −0.8210 0.6984 1.0778
205113_at NEFM neurofilament, medium polypeptide 150kDa −0.7448 0.7742 1.0743 [379], [649], [672], [673], [674], [675], [676], [677], [678], [679], [680], [681], [682], [683], [684], [685], [686], [687], [688], [689], [690], [691], [692], [693], [694], [695], [696], [697], [698], [699], [700], [701], [702]
202656_s_at SERTAD2 SERTA domain containing 2 0.7343 −0.7827 1.0732
203798_s_at VSNL1 visinin-like 1 −0.7093 0.7923 1.0634 [565], [566], [638], [641], [642], [703], [704], [705]
205352_at SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 −0.7432 0.7496 1.0555 [706], [707], [708], [709], [710], [711], [712], [713], [714]
217367_s_at ZHX3 zinc fingers and homeoboxes 3 0.7677 −0.7129 1.0477
209915_s_at NRXN1 neurexin 1 −0.7282 0.7496 1.0451
221805_at NEFL neurofilament, light polypeptide 68kDa −0.7153 0.7552 1.0402 [715], [716], [717]
213366_x_at ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 −0.7302 0.7327 1.0344
203340_s_at SLC25A12 solute carrier family 25 (mitochondrial carrier, Aralar), member 12 −0.7141 0.7444 1.0315 [718]
213967_at RALYL RALY RNA binding protein-like −0.6786 0.7758 1.0307
215161_at CAMK1G calcium/calmodulin-dependent protein kinase IG −0.7819 0.6682 1.0285
218204_s_at FYCO1 FYVE and coiled-coil domain containing 1 0.7250 −0.7222 1.0233
213222_at PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) −0.7694 0.6738 1.0227 [719], [720], [721], [722], [723], [724]
200925_at COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 −0.7532 0.6883 1.0204
38037_at HBEGF heparin-binding EGF-like growth factor 0.7222 −0.7194 1.0193 [725]
209481_at SNRK SNF related kinase −0.7048 0.7331 1.0169
201412_at LRP10 low density lipoprotein receptor-related protein 10 0.6964 −0.7399 1.0161
202941_at NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa −0.6984 0.7379 1.0160
205383_s_at ZBTB20 zinc finger and BTB domain containing 20 0.6774 −0.7569 1.0157 [726], [727]
206384_at CACNG3 calcium channel, voltage-dependent, gamma subunit 3 −0.7778 0.6516 1.0147
218888_s_at NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 −0.7899 0.6246 1.0070
212214_at OPA1 optic atrophy 1 (autosomal dominant) −0.7194 0.7024 1.0054 [728], [729], [730], [731], [732], [733], [734], [735], [736], [737], [738], [739], [740], [741], [742]
218456_at CAPRIN2 caprin family member 2 −0.7915 0.6186 1.0046
211307_s_at FCAR Fc fragment of IgA, receptor for 0.7297 −0.6886 1.0033
202724_s_at FOXO1 forkhead box O1 0.6875 −0.7270 1.0006 [743], [744], [745]
219145_at LPHN1 latrophilin 1 −0.7293 0.6826 0.9989 [746]
205711_x_at ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 −0.7153 0.6968 0.9986
55662_at C10orf76 chromosome 10 open reading frame 76 0.7632 −0.6420 0.9973
211978_x_at PPIA peptidylprolyl isomerase A (cyclophilin A) −0.7363 0.6726 0.9972 [747], [748], [749], [750]
210016_at MYT1L myelin transcription factor 1-like /// hypothetical protein LOC100134306 −0.7577 0.6395 0.9915
204072_s_at FRY furry homolog (Drosophila) −0.7456 0.6512 0.9899
219497_s_at BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) −0.6843 0.7117 0.9873
201125_s_at ITGB5 integrin, beta 5 0.7323 −0.6613 0.9867
211765_x_at PPIA peptidylprolyl isomerase A (cyclophilin A) −0.7230 0.6714 0.9866 [747], [748], [749], [750]
214057_at MCL1 Myeloid cell leukemia sequence 1 (BCL2-related) 0.7722 −0.6137 0.9864 [751]
211839_s_at CSF1 colony stimulating factor 1 (macrophage) 0.8120 −0.5590 0.9858 [752], [753], [754], [755], [756], [757], [758], [759], [760], [761], [762], [763], [764], [765], [766], [767], [768], [769], [770], [771], [772], [773], [774], [775], [776], [777], [778], [779], [780], [781], [782]
205551_at SV2B synaptic vesicle glycoprotein 2B −0.6915 0.7008 0.9846 [66]
219167_at RASL12 RAS-like, family 12 0.6226 −0.7605 0.9828
214393_at RND2 Rho family GTPase 2 0.7051 −0.6799 0.9796
212899_at CDC2L6 cell division cycle 2-like 6 (CDK8-like) 0.7319 −0.6504 0.9791
220615_s_at MLSTD1 male sterility domain containing 1 −0.6665 0.7149 0.9774
201681_s_at DLG5 discs, large homolog 5 (Drosophila) 0.7093 −0.6706 0.9761
208195_at TTN titin 0.7173 −0.6617 0.9759 [783]
202457_s_at PPP3CA protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform −0.7661 0.6016 0.9741
214150_x_at ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 0.6230 −0.7488 0.9741
204743_at TAGLN3 transgelin 3 −0.6952 0.6802 0.9726
213197_at ASTN1 astrotactin 1 −0.7069 0.6673 0.9721

The column “Dist O” shows the Euclidean distance from the origin for each gene. If the gene has a known relation with AD (ADG), the reference's codes are display in column “Ref ADG”.