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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: Biol Psychiatry. 2009 Nov 7;67(9):812–822. doi: 10.1016/j.biopsych.2009.09.016

Figure 3.

Figure 3

Intracaudate or medial prefrontal cortex (mPFC) antagonism of mGluR5 does not alter ethanol self-administration or spontaneous motor activity. (A) Mean (± SEM) responses on the ethanol (15% v/v) lever after intra-dorsomedial caudate putamen administration of the mGluR5 antagonist MPEP and a sham infusion (to left of axis break). (B) Mean (± SEM) cumulative ethanol responses across the 30-min self-administration session after intracaudate MPEP administration. (C) Mean (± SEM) cumulative distance traveled (cm) during the 30-min locomotor assessment after intracaudate administration of MPEP (10 μg). (D) Mean (± SEM) responses on the ethanol (15% v/v) lever after intra-mPFC administration of the mGluR5 antagonist MPEP and a sham infusion (to left of axis break). (E) Mean (± SEM) cumulative ethanol responses across the 30-min self-administration session after intra-mPFC MPEP administration. (F) Mean (± SEM) cumulative distance traveled (cm) during the 30 min locomotor assessment after intra-mPFC administration of MPEP (30 μg). Abbreviations as Figures 1 and 2.