Table 1.

Peripheral blood cell differential cell counts (× 10³ per μl) for Cyp1b1 knockout and wild type mice treated IP with DMBA or oil vehicle

Endpoint	Time (h)	Wild type: control	Wild type: DMBA	Cyp1b1 knockout: Control	Cyp1b1 knockout: DMBA
Lymphocytes	6	6.35 ± 0.58	3.29 ± 0.52*	5.24 ± 0.43	5.01 ± 0.25
	168	8.25 ± 0.61	3.36 ± 0.16*	7.30 ± 0.85	7.19 ± 1.16
Neutrophils	6	1.70 ± 0.22	0.90 ± 0.09*	1.65 ± 0.23	2.56 ± 0.21*
	168	0.61 ± 0.10	1.20 ± 0.41*	0.75 ± 0.10	5.71 ± 0.57*
Monocytes	6	0.2 ± 0.01	0.13 ± 0.03*	0.32 ± 0.03	0.42 ± 0.02*
	168	0.22 ± 0.02	0.04 ± 0.00*	0.23 ± 0.02	0.26 ± 0.06

Mice were injected IP with 50 mg/kg DMBA in 0.2 ml oil vehicle; controls received oil alone. Mice were euthanized at 6 or 168 h and blood collected by cardiac puncture. Total white blood cell and differential counts were performed as described in the methods.

^*Denotes p< 0.05 compared to vehicle control mice.