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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Biol Psychiatry. 2009 Dec 24;67(9):880–886. doi: 10.1016/j.biopsych.2009.10.030

Figure 2.

Figure 2

Ghrelin signaling is required for the enhancement in food CPP performance induced by calorie restriction. A. The GHSR antagonist Compound 26 (30 μg/g BW, via gavage) blocks the acquisition of food CPP in calorie-restricted mice when used before each conditioning session, whereas it is ineffective when administrated only on the test day. B. In contrast to wild-type mice, GHSR-null mice fail to show food CPP under a mild calorie-restriction protocol. Data represent the mean ± s.e.m. * p<0.05, **** p<0.000001.