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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Biol Psychiatry. 2009 Dec 24;67(9):880–886. doi: 10.1016/j.biopsych.2009.10.030

Figure 6.

Figure 6

Ghrelin increases the motivation to obtain HFD pellets in an orexin-dependent manner. Ghrelin increases the breakpoint for HFD pellets in an operant conditioning trial using a progressive ratio schedule. In contrast, SB-334867-pretreated (10 μg/g BW, i.p.) and orexin-deficient mice fail to show a ghrelin-induced increase of breakpoint for HFD pellets. Data represent the mean ± s.e.m. ** p<0.01