Table 1.
Characteristics of lung transplant recipients with BOS in the No Azithromycin and Azithromycin Cohorts
| No Azithromycin n = 95 | Azithromycin n = 78 | p* | |
|---|---|---|---|
| Female, n (%) | 47 (50) | 42 (54) | 0.57 |
| Age at Transplant, mean years ± SD | 51.6 ± 12.7 | 49.0 ± 12.8 | 0.18 |
| Underlying Disease, n (%) | 0.44 | ||
| COPD | 58 (61) | 39 (50) | |
| α1-AT | 11 (12) | 10 (13) | |
| Cystic Fibrosis | 13 (14) | 14 (18) | |
| Pulmonary Fibrosis | 9 (10) | 7 (9) | |
| Other | 4 (4) | 8 (10) | |
| Ischemic Time, mean minutes ± SD | 313 ± 68 | 321 ± 61 | 0.41 |
| Ischemic Time > 330 min | 38 (40) | 29 (37) | 0.71 |
| Date of transplant, mean date ± SD in years | 2/5/01 ± 1.65 | 6/24/01 ± 1.77 | 0.15 |
| Type of Transplant, n (%) | 1.00 | ||
| Bilateral | 91 (96) | 74 (95) | |
| Single | 4 (4) | 4 (5) | |
| PGD at T0, n (%) | 0.47 | ||
| 0 | 14 (15) | 13 (17) | |
| 1 | 39 (41) | 28 (36) | |
| 2 | 26 (27) | 17 (22) | |
| 3 | 16 (17) | 20 (26) | |
| Highest A score, n (%) | 0.03 | ||
| 0 | 22 (23) | 14 (18) | |
| 1 | 25 (26) | 12 (15) | |
| 2 | 40 (42) | 34 (44) | |
| 3 | 8 (8) | 18 (23) | |
| Highest B score, n (%) | 0.16 | ||
| 0 | 30 (32) | 16 (21) | |
| 1 | 47 (50) | 37 (47) | |
| 2 | 16 (17) | 21 (27) | |
| 3 | 2 (2) | 4 (5) | |
| Pseudomonas culture positive, n (%) | 23 (24) | 27 (35) | 0.13 |
| CMV Pneumonitis, n (%) | 51 (54) | 31 (40) | 0.07 |
| CARV, n (%) | 13 (14) | 15 (19) | 0.32 |
| Time transplant to BOS stage 1, days ± SD | 813 ± 669 | 987 ± 705 | 0.10 |
| FEV1 at BOS stage 1, mean liters ± SD | 2.11 ± 0.79 | 2.22 ± 0.63 | 0.33 |
| Number of FEV1 measurements prior to BOS stage 1 | 25.11 ± 15.22 | 26.67 ± 13.31 | 0.51 |
| Antithymocyte globulin for BOS stage 1, n (%) † | 46 (52) | 61 (78) | <0.001 |
| Time BOS stage 1 to death/censoring, mean years ± SD | 2.29 ± 1.83 | 3.26 ± 1.94 | 0.001 |
Definition of abbreviations: α1-AT = alpha1 antitrypsin deficiency; BOS = bronchiolitis obliterans syndrome; CARV = community-acquired respiratory virus; CMV = cytomegalovirus; COPD = chronic obstructive pulmonary disease; FEV1 = forced expiratory volume in one second; Highest A score = highest acute vascular rejection score; Highest B score = highest lymphocytic bronchitis score; PGD = primary graft dysfunction; SD = standard deviation.
*
Chi-squared or Fisher’s exact test for categorical variables and independent groups t-test for continuous variables.
†
represents 89 recipients in No Azithro cohort.