Figure 1.
Met-enkephalin infusion into the ventral striatum does not alter high fat chow consumption. Infusion sites in the NAcc core (A), NAcc shell (B), anterior ventrolateral striatum (C), and posterior ventrolateral striatum (D), are shown. In each site, the effects of control saline, met-enkephalin (3 concentrations), and DAMGO (1 concentration) on food intake were assessed. DAMGO reliably elicited hyperphagia (p<0.001 in all sites), while met-enkephalin increased consumption only after the 0.25 nmoles/NAcc dose in the posterior ventrolateral striatum, at a marginally significant level (p=0.049). In this and other bar graphs, bars represent mean value ± SEM. For figures 1–4, consumption is presented as grams of high fat chow consumed over a one hour session.