Fig. 6.

Summary of fate hierarchies revealed by EMS daughter cell fate transformations in various mutant backgrounds. Loss of pop-1 results in an MS to E transformation (Lin et al., 1995); loss of Wnt/MAPK function causes an E to MS transformation (Rocheleau et al., 1997; Thorpe et al., 1997); for skn-1 or med-1,2 mutant embryos, MS adopts a C-like fate, while E appears to adopt either an E or C fate (Bowerman et al., 1992; Maduro et al., 2001); loss of end-1,3 results in an E to C transformation (Maduro et al., 2005a; Zhu et al., 1997); loss of tbx-35 and ceh-51 results in a transformation of MS to C (Broitman-Maduro et al., 2009); and loss of end-1,3 and pop-1 together results in a restored partial MS lineage, and an apparent mixed fate from E that is a combination of MS and C fates (this work).