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. Author manuscript; available in PMC: 2011 Apr 15.
Published in final edited form as: Dev Biol. 2010 Feb 10;340(2):518–527. doi: 10.1016/j.ydbio.2010.02.007

Fig. 7. Models for axial regulation of metanephric kidney development.

Fig. 7

The finding of renal fusion in the NC-DTA mutants contradicts the hypothesis that degeneration of the notochord leads to renal agenesis (Model 1). In a new model (Model 2), signals from the notochord and floor plate, such as Shh, do not directly affect nephrogenesis. Instead, these signals affect the development of the midline structures and the positioning of the MM. See text for details. UB: ureteric bud; MM: metanephric mesenchyme.