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. 2010 Apr 5;189(1):171–186. doi: 10.1083/jcb.200911095

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© 2010 Sedmak and Wolfrum

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Figure 1. — Localization of IFT proteins in the retina. (A) Schema of the ciliary apparatus of a rod photoreceptor cell: the photosensitive OS linked by the CC to the IS. The CC is composed of a basal part (bC), which represents the region of the BB, and the CC shaft (sh). The shaft continues into the base of the OS (bO; number sign). Microtubules of the axoneme (Ax) extend into the OS. A centriole (Ce) is adjacent to the BB and the ciliary rootlet (CR). A black asterisk indicates the apical periciliary extension of the IS. The arrow points into the groove between the IS and CC. (B–D) Longitudinal cryosection through a mouse retina. Differential interference contrast (DIC) image (B), DAPI staining (C), and indirect immunofluorescence of anti-IFT20 (D) are shown. (E–H) Immunofluorescence of longitudinal cryosections through mouse retinas stained for IFT52 (E), -57 (F), -88 (G), and -140 (H). (I) Schema of a rod cell and connection to secondary retinal neurons (2nd) illustrating the differential localization of IFT proteins. Photoreceptor cell bodies harboring nuclei (N) are located in the ONL. Synapses (S) to secondary neurons in the OPL (white asterisks) are shown. Bar, 10 µm.