Table 2.
Risk factor | Reference group | OR* (95% CI) |
---|---|---|
Smoking status | ||
Former | 3.38 (2.20−5.20) | |
Current | Never smokers | 6.20 (4.06−9.47) |
Current smokers | ||
Duration >30 y | ≤30 y | 1.97 (1.16−3.33) |
No. cigarettes/day >20 | ≤20/d | 3.94 (2.26−6.87) |
Pack-years >40 | <40 pack-years | 3.44 (2.15−5.47) |
Menthol cigarette use | None | 0.69 (0.46−1.03) |
Former smokers | ||
Duration >30 y | 30 y | 2.43 (1.58−3.75) |
No. cigarettes/day >20 | ≤20/d | 1.75 (1.04−2.93) |
Pack-years >40 | <40 pack-years | 2.74 (1.67−4.52) |
Years since cessation >10 y | ≤10 y | 0.42 (0.27−0.67) |
Age at cessation >30 y | ≤30 y | 2.60 (1.03−6.58) |
Menthol cigarette use | None | 0.99 (0.62−1.56) |
Environmental exposures | ||
Asbestos | No exposure | 1.58 (1.18−2.12) |
Wood dusts | No exposure | 1.50 (1.09−2.05) |
Fibers | No exposure | 1.33 (0.83−2.13) |
SVF | No exposure | 2.27 (1.44−3.60) |
Benzene | No exposure | 1.17 (0.83−1.65) |
Toluene/xylene | No exposure | 1.40 (1.02−1.92) |
Dry cleaning | No exposure | 1.60 (0.76−3.37) |
Vehicle exhaust | No exposure | 1.01 (0.73−1.43) |
Pesticides | No exposure | 1.36 (0.82−2.25) |
Glues and plastics | No exposure | 1.22 (0.78−1.91) |
Comorbidities | ||
Asthma | No self-reported diagnosis | 1.11 (0.74−1.65) |
COPD | No self-reported diagnosis | 6.38 (3.24−12.59) |
Hay fever | No self-reported diagnosis | 0.68 (0.47−0.99) |
Family history | ||
Lung cancer in ≥1 FDR | No family history | 1.11 (0.76−1.61) |
Smoking related cancer in ≥1 FDR | No family history | 1.02 (0.73−1.42) |
Abbreviation: FDR, first-degree relative.
Adjusted for age, sex, and smoking status when possible.