. Author manuscript; available in PMC: 2010 Apr 14.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1111–1119. doi: 10.1158/1055-9965.EPI-07-2827

Table 3.

Distributions and risk estimates of lung cancer for spontaneous and NNK-induced micronuclei (mononucleated)

	Case patients, n (%)	Control subjects, n (%)	Odds ratio (95% CI)^*
MN as a dichotomy Pearson’s χ² test
Spontaneous
0-2	81 (58.3)	112 (86.2)	1.0
≥3	58 (41.7)	18 (13.8)	3.96 (1.98-7.92)
PPV		76.3
NNK induced
0-2	4 (2.9)	94 (72.4)	1.0
≥3	135 (91.1)	36 (27.7)	75.12 (24.46-230.68)
PPV		78.9
Micronuclei as continuous variable (multivariate logistic regression analysis)
		Spontaneous	2.10 (1.59-2.76)
		NNK-induced	5.43 (3.46-8.52)

Abbreviation: PPV, Positive predictive value.

Adjusted by age, sex, history of alcohol use, number of years smoked, and number of cigarettes smoked per day.