Table 5.
Experimental Ki inhibition constant (μM) of the different inhibitors and experimental inhibition hierarchy for mushroom and Streptomyces antibioticus tyrosinase (see references in the text). The error bar is indicated in parentheses (when given in the literature: Maddaluno et al., 1998; Conrad et al. 1994; Bubacco et al. 2000, Jimenez et al. 2001).
| Inhibiteur | Enzyme origin | |
|---|---|---|
| Mushroom (Ki) | Streptomyces antibioticus (Ki) | |
| 2-APO− (a) | 2 | |
| Deprotonated kojic acid (b) | 3.4 | |
| Deprotonated 4-hydroxybenzaldehyde (c) | 37 (+/−10) | |
| o-toluate (d) | 6.8 | |
| p-toluate (not calculated) | 80(+/−20) | 195(+/−0.9) |
| benzoate (e) | 18 (+/−1) | 800 +/−0.9 |
| 2,6-dimethylbenzoate (f) | Non inhibitor | |
| a >d> e > c > f | b >d > e | |