Figure 6.
Activated TC21/R-Ras2 and activated H-Ras, but not activated R-Ras, stimulate the migration of Nf1−/− Schwann cells. (a) Nf1−/− MSCs were cotransfected with β-galactosidase and (72L)TC21/R-Ras2-pZIP, (38V)R-Ras-pZIP, or vector control. (b) Nf1−/− MSCs were cotransfected with β-galactosidase and (87L)R-Ras-pCGN-Hyg or vector control. (c) Nf1−/− MSCs were cotransfected with β-galactosidase and (12V)H-Ras-pZIP, or vector control. Cells were tested in the cell migration assay in the presence of Nf1−/− mouse Schwann cell conditioned medium and the migration was quantified as in Figure 5. **P<0.01 compared with vector control