Table 2. Differences between diabetic and non-diabetic subjects of selected variables for the intervention period.

Data reported as median [25, 75 percentiles].

Variable	Type 2 diabetic subjects (n = 20)				Non-diabetic subjects (n = 18)				Changes between groups (deltas)
	Baseline	End	Delta	P	Baseline	End	Delta	P	P
Fibrinogen glycation (mol glucose/mol fibrinogen)	6.81 [5.64; 10.7] *†	5.02 [4.19; 5.86]	−2.49 [−3.70; −0.67]	<0.01†	3.84 [3.27; 4.20] *†	3.69 [3.27; 4.34]	−0.2 [−0.44; 0.26]	0.36	<0.001†
Ks (cm2 × 10−8)	2.45 [1.95; 2.65]	2.85 [2.24; 3.37]	0.45 [0.0; 1.48]	0.02†	2.54 [2.0; 3.15]	2.8 [2.43; 3.59]	0.06 [−0.45; 3.6]	0.7	0.16
Lag time (s)	36.5 [34.5; 38.4]	37.6 [33.2; 40.4]	0.16 [−3.28; 2.59]	0.86	38.7 [34.6; 40.9]	38.9 [33.3; 42.9]	−0.12 [−2.02; 2.41]	0.53	0.95
Slope	5.86 [4.78; 6.33] *†	5.04 [4.25; 5.81]	−0.69 [−1.02; 0.69]	0.21	3.95 [3.53; 4.64] *†	3.69 [3.32; 4.42]	0.11 [−0.31; 0.25]	0.69	0.29
Max absorbance	0.67 [0.63; 0.78]	0.65 [0.58; 0.71]	−0.03 [−0.12; 0.06]	0.19	0.70 [0.57; 0.73]	0.64 [0.56; 0.71]	−0.03 [−0.12; 0.10]	0.76	0.67
	7 Selected diabetic subjects				5 Selected non-diabetic subjects
Fibrinogen glycation (mol glucose/mol fibrinogen)	10.7 [8.41; 11.0] *†	5.07 [4.77; 7.10]	−3.60 [−6.14; −2.53]	0.02†	3.02 [2.93; 3.35]*†	3.15 [3.08; 3.15]	−0.12 [−0.20; 0.13]	0.89	0.004†
Ks (cm2 × 10−8)	2.24 [1.47; 2.50]	2.84 [1.81; 3.07]	0.46 [0.29; 0.86]	0.04†	2.79 [2.67; 4.46]	3.59 [2.80; 3.74]	0.01 [−0.87; 0.71]	0.89	0.43
Lag time (s)	36.5 [36.4; 36.7]	39.1 [38.5; 41.3]	2.59 [1.75; 2.96]	0.08	31.8 [31.1; 39.3]	40.7 [31.1; 42.9]	2.20 [2.10; 8.81]	0.08	0.94
Slope	5.86 [5.49; 6.20] *†	4.62 [4.57; 5.45]	−0.51 [−0.91; −0.41]	0.04†	3.94 [3.68; 4.24]*†	3.37 [3.01; 4.45]	0.10 [−0.31; 0.52]	0.89	0.15
Max absorbance	0.78 [0.67; 0.78]	0.66 [0.49; 0.66]	−0.12 [−0.13; −0.06]	0.08	0.73 [0.57; 0.74]	0.67 [0.56; 0.72]	−0.003 [−0.06; 0.02]	0.69	0.31
Storage modulus G' (dyne/cm2)	372 [282; 451]	324 [209; 399]	−81.3 [−114; −7.30]	0.35	227 [82.1; 389]	277 [167; 455]	70.4 [−60.3; 221]	0.35	0.43
Loss modulus G” (dyne/cm2)	32.5 [24.7; 38.4]	29.9 [19.7; 32.5]	−4.3 [−7.79; −2.17]	0.18	33.4 [8.26; 44.6]	35.8 [20.0; 48.0]	11.7 [−7.23; 14.8]	0.50	0.43
Loss tangent (tanδ)	0.09 [0.08; 0.09]*†	0.09 [0.07; 0.10]	0.006 [−0.02; 0.009]	0.92	0.10 [0.10; 0.12] *†	0.11 [0.11; 0.13]	0.03 [−0.04; 0.03]	0.69	0.66
Lysis rate (µm/min)	3.08 [2.48; 3.25]‡†	3.27 [2.92; 3.72]	0.47 [0.12; 0.62]	0.02†	8.52 [6.18; 8.59] ‡†	8.21 [6.50; 8.64]	0.33 [−0.31; 0.94]	0.35	0.87
Fiber diameter (µm)	0.086 [0.080; 0.105]	0.092 [0.083; 0.093]	0.006 [−0.006; 0.013]	0.40	0.076 [0.069; 0.092]	0.096 [0.076; 0.099]	0.008 [−0.011; 0.008]	0.89	0.86

^*Significant difference between groups at baseline.

^†Large practical relevance.

^‡p=0.06.