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. 2010 Apr 6;4:8. doi: 10.3389/fnsys.2010.00008

Figure 2.

Figure 2

Comparison of SCA-derived versions of the DMN using three different seed voxel locations proposed in the literature (A: Fox et al. , 2005 in red; B: Singh and Fawcett, 2008 in green; C: Greicius et al., 2003, in dark blue). The results of SCA analysis using these seeds are displayed (i) as maximum intensity projections (searching up to 12 voxels below the surface or slice on 3-D renderings of a single subject's high-resolution MRI; RH = right hemisphere, mid = midline, LH = left hemisphere), and (ii) as binarised thresholded Z-statistic images on selected slices in the space of the subject's high resolution MRI (cluster-corrected z = 2.3, p < 0.05). It is clear from the extent of primary (non-overlapping) colours visible (largely red and green), particularly in prefrontal, occipital lobes and subcortical regions, that variations inherent in the seed-selection process can result in a large amount of variability into SCA analysis and subsequent interpretations. (iii) ICA-derived DMN map (Colour bar shows Z-statistic values).