Table 1.
HLA class I allele frequency in HIV+ and HIV− PML patients and controls.
| Caucasians | African-Americans | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| HLA | HIV+ controls (n=1762) |
PML (n=233) |
HIV+ controls (n=241) |
PML (n=55) |
||||||
| N | % | N | % | P (OR) |
N | % | N | % | P (OR) |
|
| A2 | 445 | 25.3 | 59 | 25.3 | 1 (1.00) |
46 | 19.1 | 12 | 21.8 | 0.71 (1.18) |
| A3 | 240 | 13.6 | 20 | 8.6 |
0.03
(0.60) |
21 | 8.7 | 2 | 3.6 | 0.27 (0.40) |
| A31 | 55 | 3.1 | 3 | 1.3 |
0.15
(0.40) |
9 | 3.7 | 1 | 1.8 | 0.69 (0.48) |
| A33 | 25 | 1.4 | 6 | 2.6 |
0.17
(1.84) |
13 | 5.4 | 6 | 10.9 |
0.14
(2.15) |
| A68 | 68 | 3.9 | 10 | 4.3 | 0.72 (1.12) |
24 | 10.0 | 6 | 10.9 | 0.81 (1.11) |
| HIV+ controls (n=1798) |
PML (n=231) |
HIV+ controls (n=247) |
PML (n=51) |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N | % | N | % | P (OR) |
N | % | N | % | P (OR) |
|
| B8 | 186 | 10.3 | 29 | 12.6 | 0.31 (1.24) |
8 | 3.2 | 4 | 7.8 |
0.13
(2.54) |
| B18 | 79 | 4.4 | 19 | 8.2 |
0.02
(1.95) |
6 | 2.4 | 2 | 3.9 | 0.63 (1.64) |
| B41 | 16 | 0.9 | 4 | 1.7 | 0.27 (1.96) |
1 | 0.4 | 0 | 0.0 | 1 (0) |
| B42 | 2 | 0.1 | 0 | 0.0 | 1 (0) |
14 | 5.7 | 6 | 11.8 |
0.13
(2.22) |
| B44 | 230 | 12.8 | 26 | 11.3 | 0.60 (0.86) |
14 | 5.7 | 3 | 5.9 | 1 (1.04) |
| B50 | 18 | 1.0 | 5 | 2.2 |
0.17
(2.19) |
1 | 0.4 | 1 | 2.0 | 0.31 (4.92) |
| HIV+ controls (n=1758) |
PML (n=174) |
HIV+ controls (n=231) |
PML (n=42) |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N | % | N | % | P (OR) |
N | % | N | % | P (OR) |
|
| Cw3 | 221 | 12.6 | 23 | 13.2 | 0.81 (1.06) |
22 | 9.5 | 2 | 4.8 | 0.55 (0.48) |
| Cw4 | 204 | 11.6 | 18 | 10.3 | 0.71 (0.88) |
39 | 16.9 | 8 | 19.1 | 0.82 (1.16) |
| Cw7 | 473 | 26.9 | 55 | 31.6 |
0.18
(1.26) |
45 | 19.5 | 6 | 14.3 | 0.52 (0.69) |
| Cw12 | 130 | 7.4 | 13 | 7.5 | 1 (1.01) |
5 | 2.2 | 0 | 0.0 | 1 (0) |
Note: PML: HIV+ and HIV− PML patients, n: total number of all alleles, N: total number of specific allele, % allele frequency, calculated by dividing the total number of each allele by the total number of alleles and multiplying by 100, p-values are calculated with Fisher exact test, odds ratios reflect the likelihood of having a specific allele in the PML group versus the HIV+ control group.